Valgrind on Mac instructions. As of Sept 16 2011, a patched version of valgrind can be used on OS X 10.7 Lion. 1) Check out valgrind rev 12025 from source: svn co svn://svn.valgrind.org/valgrind/trunk@12025 valgrind 2) Download patch: https://bugs.kde.org/show_bug.cgi?id=275168#c20 3) Apply patch and build valgrind (see http://valgrind.org/downloads/repository.html) Important: Use gcc-4.2 for building (export CC=gcc-4.2 before running configure) Supression file : suppressions_mac Tested with valgrind command line: valgrind --log-file=log --show-reachable=yes --num-callers=50 --error-limit=no --leak-check=full --suppressions=suppressions_mac /Volumes/Build/qt5/qtbase/examples/widgets/calculator/calculator.app/Contents/MacOS/calculator